![]() To overcome the obstacles of easy dissolution of PVA nanofibers without crosslinking treatment and the poor electrospinnability of the PVA cross-linked nanofibers via electrospinning process, the PVA based electrospun hydrogel nanofibers are prepared with post-crosslinking method. Yang, Jen Ming Yang, Jhe Hao Tsou, Shu Chun Ding, Chian Hua Hsu, Chih Chin Yang, Kai Chiang Yang, Chun Chen Chen, Ko Shao Chen, Szi Wen Wang, Jong Shyan International Nuclear Information System (INIS) Lastly, the drug-loaded electrospun PVA mats exhibited much better release characteristics of the model drugs than drug-loaded as-cast films.Ĭell proliferation on PVA/sodium alginate and PVA/poly(γ-glutamic acid) electrospun fiber The molecular weight of the model drugs played a major role on both the rate and the total amount of drugs released from the as-prepared drug-loaded electrospun PVA mats, with the rate and the total amount of the drugs released decreasing with increasing molecular weight of the drugs. Thermal properties of the drug-loaded electrospun PVA mats were analysed by differential scanning calorimetry and thermogravimetric analysis. ![]() The 1H-nuclear magnetic resonance results confirmed that the electrospinning process did not affect the chemical integrity of the drugs. The morphological appearance of the drug-loaded electrospun PVA mats depended on the nature of the model drugs. sodium salicylate (freely soluble in water), diclofenac sodium (sparingly soluble in water), naproxen (NAP), and indomethacin (IND) (both insoluble in water), were selected as model drugs. Four types of non-steroidal anti-inflammatory drug with varying water solubility property, i.e. Mats of PVA nanofibres were successfully prepared by the electrospinning process and were developed as carriers of drugs for a transdermal drug delivery system. Taepaiboon, Pattama Rungsardthong, Uracha Supaphol, Pitt ![]() Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs ![]()
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